Correspondence Quantification in Comprehensive Two-Dimensional Liquid Chromatography

This correspondence corrects the description in a recent paper by Mondello et al., “Quantification in Comprehensive Two-Dimensional Liquid Chromatography” [Mondello, L.; Herrero, M.; Kumm, T.; Dugo, P.; Cortes, H.; Dugo, G. Anal. Chem., 2008, 80, 5418-5424], of previous research on peak integration. This correspondence also shows that the peak integration method proposed in that paper is equivalent to, but is less efficient than, simply summing the data values.